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Showing 1–14 of 14 results
Advanced filters: Author: Jeffrey S. Taube Clear advanced filters

  • The mechanisms generating the head direction cell signal in rats are not fully understood. Here, two distinct types of head direction cells in the lateral mammillary and dorsal tegmental nuclei were identified: one type is angular head velocity independent, while the second type depends on the animal’s angular head velocity.

    • Jeffrey S. Taube
    • William N. Butler
    • Ryan M. Yoder
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Many spatial correlates have been identified that form the neural basis for navigation. Two studies have now uncovered a new cell type: bidirectional cells, which fire when the head is pointing in one of two opposing directions.

    • Jeffrey S Taube
    News & Views
    Nature Neuroscience
    Volume: 20, P: 131-133

  • Single-molecule magnets are clusters of metal ions linked together by organic bridges, with properties typically arising from exchange coupling of unpaired metal electrons. In mixed-valence systems, another magnetic mechanism involving itinerant electrons can also occur and induce a high-spin ground state. Now, such electron delocalization has been observed through an imidazolate bridge — a common linker in metal-organic architectures — which may enable the construction of higher spin clusters or three-dimensional magnets.

    • Bettina Bechlars
    • Deanna M. D'Alessandro
    • Jeffrey R. Long
    Research
    Nature Chemistry
    Volume: 2, P: 362-368

  • Path integration allows animals to track their body position in planar space by relying on both external cues and internal cues. For monitoring internal cues, head direction cells in the anterodorsal thalamic nucleus are one of the best candidates for the neural mechanism underlying path integration. This study shows that head-direction cells in rats act as a mediator of path integration such that their firing matches the level of movement trajectory heading errors in a cumulative manner, and that head-direction cells correct their firing when internal error is corrected by external cues.

    • Stephane Valerio
    • Jeffrey S Taube
    Research
    Nature Neuroscience
    Volume: 15, P: 1445-1453

  • Considerable progress has been made in understanding how the brain encodes our sense of direction. This Perspective considers the link between self-motion detection and navigation circuits and discusses future challenges for establishing the neural mechanisms responsible for sensing direction in both real-world and virtual-reality environments.

    • Kathleen E Cullen
    • Jeffrey S Taube
    Reviews
    Nature Neuroscience
    Volume: 20, P: 1465-1473

  • Amyotrophic Lateral Sclerosis (ALS) is highly heritable but the mechanisms of sporadic ALS are not fully understood. In this study, the authors identify drivers of variation and disease-relevant changes in the epigenomic profile of iPSC-derived motor neuron lines generated from ALS patients and healthy controls as part of the Answer ALS program.

    • Stanislav Tsitkov
    • Kelsey Valentine
    • Ernest Fraenkel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • A machine learning approach is presented to identify dominant patterns in disease progression in amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and Parkinson’s disease. The nonlinearity of ALS progression has important clinical implications.

    • Divya Ramamoorthy
    • Kristen Severson
    • Ernest Fraenkel
    ResearchOpen Access
    Nature Computational Science
    Volume: 2, P: 605-616

  • A comprehensive analysis of RNA sequencing and single-nucleotide polymorphism (SNP) array data provides new insights into the biology of 675 human cancer cell lines

    • Christiaan Klijn
    • Steffen Durinck
    • Zemin Zhang
    Research
    Nature Biotechnology
    Volume: 33, P: 306-312

  • Answer ALS is a resource of patient-derived iPS cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This serves as a foundation to identify distinct disease subgroups.

    • Emily G. Baxi
    • Terri Thompson
    • Jeffrey D. Rothstein
    ResearchOpen Access
    Nature Neuroscience
    Volume: 25, P: 226-237

  • Permanent magnets constructed from metal ions and organic linkers using molecular design principles could bring transformative advances in areas such as energy conversion, transportation, and information storage. This comment highlights the recent discovery of a metal–organic magnet ordering at 242 °C, and discusses future research directions and possible applications involving such materials.

    • Ryan A. Murphy
    • Jeffrey R. Long
    • T. David Harris
    Comments & OpinionOpen Access
    Communications Chemistry
    Volume: 4, P: 1-4