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Showing 1–3 of 3 results
Advanced filters: Author: Jeffrey Vedanayagam Clear advanced filters

  • The Dox meiotic drive system distorts the sex ratio in Drosophila simulans. Here, the authors reconstruct the stepwise emergence, and recent amplification of Dox superfamily genes in parallel with the emergence of autosomal hairpin RNA-class siRNA loci that target subsets of these putative drivers.

    • Jeffrey Vedanayagam
    • Ching-Jung Lin
    • Eric C. Lai
    Research
    Nature Ecology & Evolution
    Volume: 5, P: 1613-1623

  • DICER is involved in the processing of miRNAs, where the RNase IIIa and IIIb domains are thought to cut the 3p and 5p hairpin arms, respectively. Here, in endometrial cancer, the authors identify an RNase IIIa mutation, which phenocopies mutations in the RNase IIIb domain.

    • Jeffrey Vedanayagam
    • Walid K. Chatila
    • Eric C. Lai
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.

    • Lijuan Kan
    • Anya V. Grozhik
    • Eric C. Lai
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16