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Showing 1–9 of 9 results
Advanced filters: Author: Jengmin Kang Clear advanced filters

  • The field of regenerative medicine would greatly benefit from the study of a non-human primate model. Here, the authors prospectively isolated two quiescent stem cell populations from the non-human primate mouse lemur.

    • Jengmin Kang
    • Abhijnya Kanugovi
    • Thomas A. Rando
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Apart from the enzymatic role of ketohexokinase isoform A (KHK-A) in fructose metabolism the alternative physiological functions of the enzyme are unclear. Here, the authors show that KHK-A mediates fructose-induced metastasis in breast cancer through a nuclear role in repressing the transcriptional activity of the cell-adhesion molecule CDH1.

    • Jiyoung Kim
    • Jengmin Kang
    • Jong-Wan Park
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

    • George Crowley
    • Robert C. Jones
    • Stephen R. Quake
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • During ageing, S-adenosylmethionine (SAM) is depleted from muscle stem cells (MuSCs) because of increased synthesis of the polyamine spermidine, leading to loss of heterochromatin and dysfunction of MuSCs. SAM restoration rescues the mouse MuSC defects.

    • Jengmin Kang
    • Daniel I. Benjamin
    • Thomas A. Rando
    Research
    Nature Metabolism
    Volume: 6, P: 153-168

  • Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

    • Antoine de Morree
    • Iwijn De Vlaminck
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 173-184

  • Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

    • Camille Ezran
    • Shixuan Liu
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 185-196

  • More effective strategies are needed to prevent prostate cancer metastasis. Here they report CBP/p300-interacting transactivator with E/D-rich carboxy-terminal domain-2 (CITED2) to interact with nucleolin, p300, and PRMT5 subunits, and reveal a role of CITED2-nucleolin axis in prostate cancer metastasis.

    • Seung-Hyun Shin
    • Ga Young Lee
    • Jong-Wan Park
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

    • Shixuan Liu
    • Camille Ezran
    • James E. Ferrell Jr.
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27