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Showing 1–2 of 2 results
Advanced filters: Author: Jenna Moyer Clear advanced filters

  • Whole-genome sequencing of matched serial tumours from patients identifies two key mutagenic factors (APOBEC3 and chemotherapy) and extrachromosomal DNA-forming structural variants that drive treatment resistance in urothelial cancer.

    • Duy D. Nguyen
    • William F. Hooper
    • Bishoy M. Faltas
    ResearchOpen Access
    Nature
    Volume: 635, P: 219-228

  • The transition of androgen receptor-dependent prostate cancer to a therapy resistant cancer with neuroendocrine phenotype is an important process that remains poorly understood. Here, the authors show that PKCλ/ι-loss promotes epigenetic reprogramming resulting in a TGFβ resistance programme via transcriptional upregulation of translational machinery.

    • Shankha S. Chatterjee
    • Juan F. Linares
    • Maria T. Diaz-Meco
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23