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Showing 1–3 of 3 results
Advanced filters: Author: Jenna R. Mattice Clear advanced filters

  • The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.

    • Sahiti Kuppa
    • Jaigeeth Deveryshetty
    • Edwin Antony
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Mediator proteins such as BRCA2 and Rad52 direct formation of Rad51 filaments in Homologous Recombination. Here, the authors present cryoEM structures of Saccharomyces cerevisiae Rad52 revealing a homodecamer and Rad51 binding to two regions in Rad52.

    • Jaigeeth Deveryshetty
    • Rahul Chadda
    • Edwin Antony
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • RPA is a master coordinator of DNA metabolism. Here, authors uncover that RPA is regulated by an Aurora B-signaling circuit that is critical for chromosome segregation in mitosis. Distinct phosphorylation of RPA70 modulates accessibility of RPA domains.

    • Poonam Roshan
    • Sahiti Kuppa
    • Sofia Origanti
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19