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Advanced filters: Author: Jennifer M. Umhoefer Clear advanced filters

Integrated epigenetic and genetic programming of primary human T cells

Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

Laine Goudy
Alvin Ha
Luke A. Gilbert
ResearchOpen Access21 Oct 2025
Nature Biotechnology

P: 1-12
Central control of dynamic gene circuits governs T cell rest and activation

Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.

Maya M. Arce
Jennifer M. Umhoefer
Alexander Marson
ResearchOpen Access11 Dec 2024
Nature

Volume: 637, P: 930-939
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells

Functional characterization of the regulatory landscape of the adjacent costimulatory genes CD28, CTLA4 and ICOS in primary human T cell subsets identifies context-dependent programs controlling this locus critical for immune homeostasis.

Cody T. Mowery
Jacob W. Freimer
Alexander Marson
ResearchOpen Access29 May 2024
Nature Genetics

Volume: 56, P: 1156-1167
Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells

Andrew S. Khalil
Xiaohua Yu
William L. Murphy
ResearchOpen Access27 Oct 2017
Scientific Reports

Volume: 7, P: 1-12

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