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Showing 1–3 of 3 results
Advanced filters: Author: Jennifer Milbank Clear advanced filters

  • Several patients with metastatic prostate cancer have been shown to harbour tumours with markedly high mutation rates. Here, the authors characterise hypermutation in advanced prostate cancer samples and show that these samples have somatic mismatch repair gene mutations and microsatellite instability.

    • Colin C. Pritchard
    • Colm Morrissey
    • Peter S. Nelson
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-6

  • Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to distinguish healthy, pre-leukaemic and leukaemic stem cells in AML.

    • Lars Velten
    • Benjamin A. Story
    • Lars M. Steinmetz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Targeted sequencing of perturbation effects offers a sensitive approach to capture genes of interest in CRISPR-mediated screens, enabling genome-scale screens at higher scale and lower cost than whole-transcriptome Perturb-seq.

    • Daniel Schraivogel
    • Andreas R. Gschwind
    • Lars M. Steinmetz
    Research
    Nature Methods
    Volume: 17, P: 629-635