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Showing 1–5 of 5 results
Advanced filters: Author: Jens L. Hukelmann Clear advanced filters

  • In a non-prespecified interim analysis of a phase 1 trial, autologous PRAME-directed TCR T cell therapy was safe and elicited durable responses in patients with recurrent and/or treatment-refractory PRAME+ advanced solid tumors, including melanoma and synovial sarcoma.

    • Martin Wermke
    • Dejka M. Araujo
    • Cedrik M. Britten
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2365-2374

  • Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expression to control NK cell metabolism and effector function.

    • Róisín M. Loftus
    • Nadine Assmann
    • David K. Finlay
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Fgf4 is a critical signal driving embryonic stem cell (ESC) exit from pluripotency and differentiation. Here the authors identify EPHA2 as a target of FGF4 signalling in ESCs, and show that EPHA2-EFNA1 signalling promotes pluripotent gene expression and suppresses commitment through repression of ERK1/2 activation.

    • Rosalia Fernandez-Alonso
    • Francisco Bustos
    • Greg M. Findlay
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Cantrell and colleagues perform a comparative quantitative mass spectrometric analysis of the proteomes of naïve and activated CD4+ and CD8+ T cells. Proteomes are dynamically regulated and mTORC1 inhibition leads to differential consequences depending on cell state.

    • Andrew J. M. Howden
    • Jens L. Hukelmann
    • Doreen A. Cantrell
    Research
    Nature Immunology
    Volume: 20, P: 1542-1554

  • Proteomic profiling can provide new insight into the cellular regulation of effector functions. Cantrell and colleagues report discordant mRNA profiles and protein profiles in activated CD8+ T cells and reveal new roles for mTORC1 in regulating the function of cytotoxic T lymphocytes.

    • Jens L Hukelmann
    • Karen E Anderson
    • Doreen A Cantrell
    Research
    Nature Immunology
    Volume: 17, P: 104-112