Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Jens Preussner Clear advanced filters

  • Cardiac progenitor cells (CPCs) form cardiomyocytes, pericytes, smooth muscle and endothelial cells during embryonic development. Here, the authors characterize mouse CPCs marked by Nkx2.5 and Isl1 from E7.5 to E9.5 by single cell RNA-seq and ATAC-seq, showing fate transitions involve distinct open chromatin state.

    • Guangshuai Jia
    • Jens Preussner
    • Thomas Braun
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Footprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles and apply it to zygotic development datasets.

    • Mette Bentsen
    • Philipp Goymann
    • Mario Looso
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.

    • Matthias S. Leisegang
    • Jasleen Kaur Bains
    • Ralf P. Brandes
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Abnormal alveolar development and homeostasis are common features of pulmonary disease. Here the authors show that Myh10 expression is reduced in emphysema patients, and that Myh10 loss of function impairs alveolar formation and lung morphogenesis via upregulation of matrix metalloproteinase activity and altered matrix remodeling.

    • Hyun-Taek Kim
    • Wenguang Yin
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion via FFAR1 activation.

    • Sorin Tunaru
    • Remy Bonnavion
    • Stefan Offermanns
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Tubulogenesis is required for the formation of many internal structures including the trachea. Here, the authors show that the potassium channel KCNJ13 regulates tracheal tube formation, with shorter tracheas forming in mutant mice due in part to changes in actin organization in tracheal smooth muscle cells.

    • Wenguang Yin
    • Hyun-Taek Kim
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13