High-mobility group box 1 (HMGB1) is actively secreted from inflammatory cells and acts via a non-cell autonomous mechanism to mediating cell proliferation and migration. The authors sought to determine the role of HMGB1 in modulation of dopaminergic neurons. Their results suggest that an increase of HMGB1, released from astrocytes, upregulates TH expression in a Parkinsonian mouse model, thereby maintaining dopaminergic neuronal functions.
- Soo Jeong Kim
- Min Jeong Ryu
- Gi Ryang Kweon
