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Showing 1–4 of 4 results
Advanced filters: Author: Jeremie Vitte Clear advanced filters

  • Schwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand production in NF2-mutant Schwann cells.

    • Christine Chiasson-MacKenzie
    • Jeremie Vitte
    • Andrea I. McClatchey
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.

    • Jeremie Vitte
    • Fuying Gao
    • Marco Giovannini
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Isakson et al. report a genetically engineered minipig model of Neurofibromatosis Type 1 (NF1) that exhibits clinical hallmarks of the disease, including neurofibromas and optic pathway glioma. This model may expedite the development of imaging methods, biomarkers, and therapies for NF1 patients.

    • Sara H. Isakson
    • Anthony E. Rizzardi
    • Adrienne L. Watson
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-11