Mice lacking kinase suppressor of Ras-1 (Ksr1) are highly susceptible to Pseudomonas aeruginosa, a bacterium that often causes infections in people with cystic fibrosis. Ksr1 recruits inducible nitric oxide synthase and heat shock protein-90 to release nitric oxide upon infection, enhancing bactericidal activity.
- Yang Zhang
- Xiang Li
- Erich Gulbins
