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Showing 1–10 of 10 results
Advanced filters: Author: Jeremy Worley Clear advanced filters

  • Toxicities limit combination of PARP inhibitors (PARPi) and chemotherapy in patients with germline BRCA1 and BRCA2 pathogenic variant (gBRCAm) breast cancer. Here, the authors report a preclinical study followed by a randomised phase II/III clinical trial investigating the addition of a gap between chemotherapy (carboplatin and paclitaxel) and PARPi (olaparib), in patients with early gBRCAm breast cancer.

    • Jean E. Abraham
    • Lenka Oplustil O’Connor
    • Helena M. Earl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A study details the results of the PARTNER trial, a prospective, randomized controlled trial of the use of neoadjuvant olaparib with carboplatin–paclitaxel chemotherapy in patients with triple-negative breast cancer who were germline BRCA1 and BRCA2 wild type.

    • Jean E. Abraham
    • Karen Pinilla
    • Helena M. Earl
    ResearchOpen Access
    Nature
    Volume: 629, P: 1142-1148

  • Sequencing the genomes of two enteropneusts reveals complex genomic organization and developmental innovation in the ancestor of deuterostomes, a group of animals including echinoderms (starfish and their relatives) and chordates (which includes humans).

    • Oleg Simakov
    • Takeshi Kawashima
    • John Gerhart
    ResearchOpen Access
    Nature
    Volume: 527, P: 459-465

  • The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

    • Barbara A. Methé
    • Karen E. Nelson
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 215-221

  • The beetle Tribolium castaneum is a commonly used laboratory model, combining the ease of systematic RNAi experiments like those in Caenorhabditis elegans, with biology that is more representative of most insects than Drosophila melanogaster. A large consortium has sequenced and analysed the genome of the red flour beetle, creating a resource for biologists everywhere.

    • Stephen Richards
    • Richard A. Gibbs
    • Gregor Bucher
    ResearchOpen Access
    Nature
    Volume: 452, P: 949-955

  • The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

    • Curtis Huttenhower
    • Dirk Gevers
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 207-214

  • An analysis of the finished sequence of human chromosome 12 representing 4.5% of the human genome determines that chromosome 12 hosts a number of genes mutated in specific cancers, as well as movement disorders and potentially Alzheimer's disease.

    • Steven E. Scherer
    • Donna M. Muzny
    • Richard A. Gibbs
    Research
    Nature
    Volume: 440, P: 346-351