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Showing 1–3 of 3 results
Advanced filters: Author: Jermaine L. Jenkins Clear advanced filters

  • Despite advances in enzyme design and engineering, the development of biocatalysts featuring a combination of tailored stereoselectivity with broad substrate scope has been very difficult. Focusing on a new-to-nature reaction, the authors report a mechanism-based, multi-state computational design workflow for the generation of ‘generalist’ cyclopropanases capable of transforming a broad range of substrates with tailored and divergent stereoselectivity.

    • Zhuofan Shen
    • Mary G. Siriboe
    • Rudi Fasan
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • Riboswitches contain an aptamer domain that recognizes a metabolite and an expression platform that regulates gene expression. Here the authors report the crystal structure of a preQ1-sensing riboswitch from Carnobacterium antarcticus that shows two metabolites in a single binding pocket.

    • Griffin M. Schroeder
    • Chapin E. Cavender
    • Joseph E. Wedekind
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • The pre-mRNA splicing factor U2AF65 recognizes 3′ splice sites in human gene transcripts, but the details are not fully understood. Here, the authors report U2AF65 structures and single molecule FRET that reveal mechanistic insights into splice site recognition.

    • Anant A. Agrawal
    • Enea Salsi
    • Clara L. Kielkopf
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14