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Showing 1–11 of 11 results
Advanced filters: Author: Jernej Murn Clear advanced filters

  • Cellular quiescence is a reversible dormant state that helps cells survive stress, support tissue regeneration, and promote longevity. Here, the authors show that blocking ribosomal RNA production by rapid depletion of RNase MRP induces a long-lasting quiescence-like state in human cells.

    • Yuan Liu
    • Shiyang He
    • Jernej Murn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • This study details how RNA-binding sites evolved between human and mouse, focusing on the conserved neuronal protein, Unkempt. The authors uncover that RNAbinding proteins often change binding sites and regulation across species even when binding motifs are conserved.

    • Sarah E. Harris
    • Maria S. Alexis
    • Daniel Dominguez
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Protein methylation was discovered over 50 years ago, but only with the advent of genomic and proteomic technologies could its mechanisms and cellular functions be studied in detail. Shi and Murn discuss the seminal discoveries in protein methylation research and highlight future directions for this field.

    • Jernej Murn
    • Yang Shi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 517-527

  • Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differentiation of myeloid stem and progenitor cells into a mixed lineage state.

    • Reuben Franklin
    • Yiming Guo
    • Sihem Cheloufi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • How RNA-binding proteins (RBPs) regulate gene expression via effectors of RNA processing is unclear. Here, the authors dissect the effector interface of an essential RBP, Unkempt, and investigate its contribution to translational control in cells.

    • Kriti Shah
    • Shiyang He
    • Jernej Murn
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • This Review surveys the known mechanisms of communication between RBPs and their effectors and their roles in reducing the complexity of RNA networks. The authors review the emerging roles of RBP–effector interactions in the control of RNA processing and regulation of biological outcomes, and their contribution to human health and disease.

    • Shiyang He
    • Eugene Valkov
    • Jernej Murn
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 276-294

  • RNA interference screens were used to identify chromatin-associated factors that impede reprogramming of somatic cells into iPS cells; suppression of the chromatin assembly factor CAF-1 enhances the generation of iPS cells by rendering chromatin more accessible to pluripotency transcription factors.

    • Sihem Cheloufi
    • Ulrich Elling
    • Konrad Hochedlinger
    Research
    Nature
    Volume: 528, P: 218-224