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Showing 1–4 of 4 results
Advanced filters: Author: Jerome Ozkan Clear advanced filters

  • The interplay between hypoxic and acidic conditions in the tumor microenvironment is unclear. Here, the authors show that hypoxic and acidic tumor cells do not fully overlap and display a symbiotic interaction, relying on unsaturated fatty acids, which can be therapeutically targeted by inhibiting stearoylCoA desaturase 1 (SCD1).

    • Katarzyna Głowacka
    • Sébastien Ibanez
    • Olivier Feron
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteric Yoda1 binding pocket located in the putative mechanosensory domain.

    • Wesley M. Botello-Smith
    • Wenjuan Jiang
    • Yun Luo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Exome sequencing of a worldwide panel of 487 wheat genotypes, including landraces, cultivars and modern varieties, sheds light on wheat genomic diversity and the evolution of modern bread wheat.

    • Caroline Pont
    • Thibault Leroy
    • Jérôme Salse
    Research
    Nature Genetics
    Volume: 51, P: 905-911