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Regional and cell specific bioactivity of injectable extracellular matrix biomaterials in myocardial infarction

Myocardial infarction disrupts cardiac repair mechanisms, limiting regeneration. Here, the authors show that extracellular matrix therapies activate spatial and cell-specific pro reparative programs, revealed through spatial transcriptomics and snRNA-seq.

Joshua M. Mesfin
Van K. Ninh
Karen L. Christman
ResearchOpen Access24 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues

Intravascularly infused extracellular matrix from ventricular myocardium binds to leaky vasculature and induces the regeneration of inflamed heart tissue, as shown in rats and pigs.

Martin T. Spang
Ryan Middleton
Karen L. Christman
Research29 Dec 2022
Nature Biomedical Engineering

Volume: 7, P: 94-109

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Regional and cell specific bioactivity of injectable extracellular matrix biomaterials in myocardial infarction

Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues

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