Nature Search

Influence of obesity on the risk of esophageal disorders

Obesity is associated with an increased risk of the intimately related esophageal disorders GERD, Barrett esophagus and esophageal adenocarcinoma. In this Review, Jesper Lagergren evaluates the effect of BMI and body fat distribution on the risk of these esophageal conditions and discusses the potential underlying mechanisms.

Jesper Lagergren
Reviews06 Jun 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 340-347
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

In obesity, mitochondrial communication with the nucleus may be disrupted. Here, the authors use Finnish twin data to link obesity-related changes in mitochondrial DNA quantity with the methylation and expression of SH3BP4 in adipose tissue.

Aino Heikkinen
Vivienne F. C. Esser
Miina Ollikainen
ResearchOpen Access12 May 2025
Nature Communications

Volume: 16, P: 1-14
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen et al. report the first results from the SCALLOP consortium, a collaborative framework for pQTL mapping and biomarker analysis of proteins on the Olink platform. A total of 315 primary and 136 secondary pQTLs for 85 circulating cardiovascular proteins from over 30,000 individuals were identified and replicated to yield new insights for translational studies and drug development.

Lasse Folkersen
Stefan Gustafsson
Anders Mälarstig
Research16 Oct 2020
Nature Metabolism

Volume: 2, P: 1135-1148
Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C₄, an intracrine mediator of cell death. Structural, biochemical and computational analyses of human MGST2 suggest a mechanism employed by the enzyme to restrict catalysis to only one active site within the MGST2 trimer.

Madhuranayaki Thulasingam
Laura Orellana
Jesper Z. Haeggström
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-12
Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors

Rubén Ferreira
Jesper R. Nilsson
Morten Grøtli
ResearchOpen Access06 May 2015
Scientific Reports

Volume: 5, P: 1-8
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

Anna Andersson, Tanja Gruber, James Downing and colleagues report a genomic analysis of infant acute lymphoblastic leukemias with MLL rearrangements. They identify recurrent activating mutations in tyrosine kinase, phosphatidylinositol 3-kinase and RAS pathway genes but find that these mutations were often present in minor subclones and lost at the time of relapse.

Anna K Andersson
Jing Ma
James R Downing
Research02 Mar 2015
Nature Genetics

Volume: 47, P: 330-337
Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Common genetic variants in structural proteins contribute to risk of atrial fibrillation (AF). Here, using whole-exome sequencing, the authors identify rare truncating variants in TTN that associate with familial and early-onset AF and show defects in cardiac sarcomere assembly in ttn.2-mutant zebrafish.

Gustav Ahlberg
Lena Refsgaard
Morten S. Olesen
ResearchOpen Access17 Oct 2018
Nature Communications

Volume: 9, P: 1-11
A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos

David Bliman
Jesper R. Nilsson
Morten Grøtli
ResearchOpen Access24 Aug 2015
Scientific Reports

Volume: 5, P: 1-9
Multi-ethnic genome-wide association study for atrial fibrillation

This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

Carolina Roselli
Mark D. Chaffin
Patrick T. Ellinor
Research11 Jun 2018
Nature Genetics

Volume: 50, P: 1225-1233
Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer

Nadia Øgaard
Sarah Østrup Jensen
Claus Lindbjerg Andersen
ResearchOpen Access10 Oct 2024
British Journal of Cancer

Volume: 131, P: 1707-1715
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon

In the first-ever Undiagnosed Hackathon, nearly 100 experts from 28 countries combined advanced phenotyping and genomic techniques for 48 hours, ultimately providing diagnoses to 40% of the previously undiagnosed families. This inspiring model demonstrates the power of multidisciplinary collaboration and patient partnership in precision diagnostics.

Angelica Maria Delgado-Vega
Helene Cederroth
Ann Nordgren
Comments & Opinion21 Oct 2024
Nature Genetics

Volume: 56, P: 2287-2294
Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

Peter Olofsson
Jens Holmberg
Rikard Holmdahl
Research02 Dec 2002
Nature Genetics

Volume: 33, P: 25-32
¹⁸F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy

Marina Simón
Jesper Tranekjær Jørgensen
Andreas Kjaer
ResearchOpen Access05 May 2020
Scientific Reports

Volume: 10, P: 1-9
Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis

Laura Andreasen
Litten Bertelsen
Morten S. Olesen
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
Next-generation sequencing of AV nodal reentrant tachycardia patients identifies broad spectrum of variants in ion channel genes

Laura Andreasen
Gustav Ahlberg
Jesper H. Svendsen
Research02 Feb 2018
European Journal of Human Genetics

Volume: 26, P: 660-668
Brugada syndrome risk loci seem protective against atrial fibrillation

Laura Andreasen
Jonas B Nielsen
Morten S Olesen
Research26 Mar 2014
European Journal of Human Genetics

Volume: 22, P: 1357-1361
Interbase-FRET binding assay for pre-microRNAs

Mattias Bood
Anna Wypijewska del Nogal
Morten Grøtli
ResearchOpen Access30 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
High diagnostic yield in skeletal ciliopathies using massively parallel genome sequencing, structural variant screening and RNA analyses

Anna Hammarsjö
Maria Pettersson
Giedre Grigelioniene
ResearchOpen Access20 Apr 2021
Journal of Human Genetics

Volume: 66, P: 995-1008
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

Nina Gustafsson Sheppard
Lisa Jarl
Roland Nilsson
ResearchOpen Access13 Oct 2015
Scientific Reports

Volume: 5, P: 1-11
Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics

Jesper R. Nilsson
Tom Baladi
Anders Dahlén
ResearchOpen Access31 May 2021
Scientific Reports

Volume: 11, P: 1-13
Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Jens Bo Andersen
Louise Dahl Hultqvist
Tim Tolker-Nielsen
ResearchOpen Access09 Jul 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-13
Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

Luca Mazzurana
Paulo Czarnewski
Jenny Mjösberg
ResearchOpen Access08 Jan 2021
Cell Research

Volume: 31, P: 554-568
Early detection of colorectal neoplasia: application of a blood-based serological protein test on subjects undergoing population-based screening

Jakob Kleif
Lars Nannestad Jørgensen
Hans Jørgen Nielsen
Research28 Jan 2022
British Journal of Cancer

Volume: 126, P: 1387-1393
A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

Thea Hyttel Hansen
Yannan Yan
Nicole Schmitt
ResearchOpen Access29 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

Christian Paludan-Müller
Jonas Ghouse
Morten S. Olesen
Research01 May 2019
European Journal of Human Genetics

Volume: 27, P: 1427-1435
SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population

Adam Ameur
Johan Dahlberg
Ulf Gyllensten
ResearchOpen Access23 Aug 2017
European Journal of Human Genetics

Volume: 25, P: 1253-1260
LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

Y. Vladimir Pabon-Martinez
You Xu
Rula Zain
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-16
The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model

Peter Agger
Satyan Lakshminrusimha
Robin H. Steinhorn
Research17 Dec 2015
Pediatric Research

Volume: 79, P: 565-574

Search

Influence of obesity on the risk of esophageal disorders

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos

Multi-ethnic genome-wide association study for atrial fibrillation

Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer

Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

¹⁸F-FDG positron emission tomography and diffusion-weighted magnetic resonance imaging for response evaluation of nanoparticle-mediated photothermal therapy

Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis

Next-generation sequencing of AV nodal reentrant tachycardia patients identifies broad spectrum of variants in ion channel genes

Brugada syndrome risk loci seem protective against atrial fibrillation

Interbase-FRET binding assay for pre-microRNAs

High diagnostic yield in skeletal ciliopathies using massively parallel genome sequencing, structural variant screening and RNA analyses

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

Early detection of colorectal neoplasia: application of a blood-based serological protein test on subjects undergoing population-based screening

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model

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