The ability to effectively assess tumor margins for brain tumor resection is a crucial factor in determining outcome in patients with brain tumors. Moritz Kircher and colleagues have developed a gold-silica nanoparticle that provides a triple-mode imaging capability of magnetic resonance, photoacoustic and Raman imaging, capitalizing on the complementary strengths of each modality for noninvasively delineating brain tumor margins both preoperatively and intraoperatively. The approach was tested in several mouse models, including one that recapitulates the infiltrating growth pattern of human gliomas.
- Moritz F Kircher
- Adam de la Zerda
- Sanjiv S Gambhir
