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Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al¹⁸F-RESCA method

This protocol describes a method for direct fluorine-18 labeling of heat-sensitive proteins for PET imaging. After conjugation to RESCA chelators, proteins of interest can be radiolabeled with Al¹⁸F at room temperature in an aqueous medium.

Frederik Cleeren
Joan Lecina
Guy Bormans
Protocols24 Sept 2018
Nature Protocols

Volume: 13, P: 2330-2347

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Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al18F-RESCA method

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Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al¹⁸F-RESCA method