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Advanced filters: Author: Jessica Denom Clear advanced filters

  • The regulation of energy homeostasis by centrally-produced GLP-1 is not yet fully understood. Here, authors show that GLP-1 neuronal circuitry in the olfactory bulb reduces food intake and enhances insulin secretion in obese mice. The increase in insulin secretion is mediated by a GABA-dependent relay in the paraventricular hypothalamus and decreased sympathetic nerve activity.

    • Mireia Montaner
    • Jessica Denom
    • Christophe Magnan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14