Clostridium difficile is the major cause of antibiotic-induced diarrhoea. It has been suggested that one of C. difficile's virulence factors, toxin B, is activated by a host protease upon cell entry. This study demonstrates that toxin cleavage is an autocatalytic process induced by host inositolphosphate.
- Jessica Reineke
- Stefan Tenzer
- Christoph von Eichel-Streiber
