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Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity

Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through immunoediting.

Kok Haw Jonathan Lim
Oliver Schulz
Caetano Reis e Sousa
ResearchOpen Access02 Jan 2026
Nature Immunology

Volume: 27, P: 72-81
Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

Evidence of protective and homeostatic roles for IgE is relatively limited. Strid and colleagues demonstrate that γδ T cells induce switching to IgE that provides protection against experimentally induced epithelial cancer.

Greg Crawford
Mark David Hayes
Jessica Strid
Research16 Jul 2018
Nature Immunology

Volume: 19, P: 859-870
γδ T cells get adaptive

Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus.

Bruno Silva-Santos
Jessica Strid
News & Views22 Mar 2017
Nature Immunology

Volume: 18, P: 370-372
Local immune response to food antigens drives meal-induced abdominal pain

In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans.

Javier Aguilera-Lizarraga
Morgane V. Florens
Guy E. Boeckxstaens
Research13 Jan 2021
Nature

Volume: 590, P: 151-156
The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Elisabeth Serger
Lucia Luengo-Gutierrez
Simone Di Giovanni
Research22 Jun 2022
Nature

Volume: 607, P: 585-592
IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin

Epidermal intraepithelial lymphocytes (IEL) produce IL-13, but the physiological role of this cytokine production is not clear. Here the authors show that IEL-production of IL-13 is a vital lymphoid stress surveillance mechanism driving crosstalk with epithelial cells to maintain tissue homeostasis and inhibit chemical carcinogenesis in mice.

Tim Dalessandri
Greg Crawford
Jessica Strid
ResearchOpen Access30 Jun 2016
Nature Communications

Volume: 7, P: 1-12
Mast cells link immune sensing to antigen-avoidance behaviour

Mast cells are shown to function as sensor cells linking antigen recognition in type 2 immunity to antigen-specific avoidance behaviour, preventing immune activation and inflammation.

Thomas Plum
Rebecca Binzberger
Hans-Reimer Rodewald
ResearchOpen Access12 Jul 2023
Nature

Volume: 620, P: 634-642
Sestrins induce natural killer function in senescent-like CD8⁺ T cells

Akbar and colleagues show that sestrins induce the reprogramming of non-proliferative, senescent-like CD27^–CD28^–CD8⁺ T cells to acquire an innate-like killing activity modulated by the NK receptor NKG2D and the adaptor molecule DAP12.

Branca I. Pereira
Roel P. H. De Maeyer
Arne N. Akbar
Research30 Mar 2020
Nature Immunology

Volume: 21, P: 684-694
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

Jessica Strid
Scott J Roberts
Michael Girardi
Research06 Jan 2008
Nature Immunology

Volume: 9, P: 146-154

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