ASCL1 and OLIG2 are two basic-helix-loop-helix transcription factors that are highly co-expressed in glioblastoma (GBM). Here the authors find these two transcription factors function redundantly and are required for brain tumor initiation in a mouse model of GBM, while they possess inverse roles in determining tumor cell types and cell migration ability.
- Bianca L. Myers
- Kathryn J. Brayer
- Tou Yia Vue
