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Photoelectrochemical oxidative C(sp³)−H borylation of unactivated hydrocarbons

Organoboron compounds are of high interest in organic synthesis due to the versatility of boryl substituents that allows access to further modifications. Here, the authors report on the development of an oxidative C(sp³)−H borylation reaction under metal- and oxidant-free conditions, enabled by photoelectrochemical strategy

Ping-Fu Zhong
Jia-Lin Tu
Wujiong Xia
ResearchOpen Access16 Oct 2023
Nature Communications

Volume: 14, P: 1-11
Preclinical assessment of the distribution, metabolism, and excretion of S-propargyl-cysteine, a novel H₂S donor, in Sprague-Dawley rats

Yuan-ting Zheng
Jian-hua Zhu
Wei-min Cai
Research30 Apr 2012
Acta Pharmacologica Sinica

Volume: 33, P: 839-844
EGFR-targeting, β-defensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis

Wen-Juan Liu
Xiu-Jun Liu
Yong-Su Zhen
Research16 Jul 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1777-1786
Protein interactions, network pharmacology, and machine learning work together to predict genes linked to mitochondrial dysfunction in hypertrophic cardiomyopathy

Jia-lin Chen
Di Xiao
Zhong-gui Shan
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-23
Identification of potential LncRNAs as papillary thyroid carcinoma biomarkers based on integrated bioinformatics analysis using TCGA and RNA sequencing data

Jia-Lin Feng
Wen-Jie Zheng
Jun Chen
ResearchOpen Access16 Mar 2023
Scientific Reports

Volume: 13, P: 1-15
Holistic bursting cells store long-term memory in auditory cortex

Previous work has identified cells in L2/3 of auditory cortex which strongly respond with bursting to a specific learned chord, but not to single component tones in an auditory task. Here the authors show that these cells correlate with the behavioral relevance of the learned composite sounds.

Ruijie Li
Junjie Huang
Hongbo Jia
ResearchOpen Access07 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Exosomal circRHCG promotes breast cancer metastasis via facilitating M2 polarization through TFEB ubiquitination and degradation

Hong-yu Shen
Jia-lin Xu
Yuan Mao
ResearchOpen Access29 Jan 2024
npj Precision Oncology

Volume: 8, P: 1-16
Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats

Jia-Lin Song
Wei Zheng
Cun-Yi Fan
ResearchOpen Access19 May 2017
Experimental & Molecular Medicine

Volume: 49, P: e332
Enediyne-activated, EGFR-targeted human β-defensin 1 has therapeutic efficacy against non-small cell lung carcinoma

In this study, a novel epidermal growth factor receptor (EGFR)-targeted, human β-defensin 1-tailored fusion protein, Ec-LDP-DF, and its enediyne-integrated analogue, Ec-LDP(AE)-DF, have been prepared by genetic engineering and molecular reconstitution. The fusion protein Ec-LDP(AE)-DF displays extremely potent cytotoxicity and might be highly effective for non-small cell lung cancer therapy and useful for other EGFR-targeted therapeutics.

Wen-juan Liu
Kun-li Zhu
Hui Zhu
Research11 Sept 2018
Laboratory Investigation

Volume: 98, P: 1538-1548

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