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Showing 1–4 of 4 results
Advanced filters: Author: Jiafei Mao Clear advanced filters

  • NMR to resolve the subtype specificity of two peptide ligands for human bradykinin receptors B1R and B2R shows different presentations of the peptide termini toward the receptor and interactions with nonconserved receptor binding-pocket residues.

    • Lisa Joedicke
    • Jiafei Mao
    • Clemens Glaubitz
    Research
    Nature Chemical Biology
    Volume: 14, P: 284-290

  • As protein synthesis takes place, newly synthesized polypeptide chain passes through the ribosomal exit tunnel, which can accommodate up to 70 residues in the case of a helical peptide. Here the authors show that oxidation of cysteine residues in the nascent chain can occur within the ribosome exit tunnel, where sufficient space exists for the formation of disulfide bonds.

    • Linda Schulte
    • Jiafei Mao
    • Harald Schwalbe
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Dynamic nuclear polarization (DNP) greatly improves the NMR sensitivity, but its implementation in aqueous solutions is challenging. Here the authors demonstrate carbon polarization enhancement via in situ Overhauser DNP in small biomolecules in water at room temperature and high magnetic field.

    • Danhua Dai
    • Xianwei Wang
    • Jiafei Mao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15