Nature Search

Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes

The authors use Perturb-seq analysis in human pancreatic islet beta cells, as well as in vivo and in vitro analyses, to identify potential therapeutic targets for type 2 diabetes, including ZZEF1, which regulates insulin synthesis and cellular stress in islet β cells.

Jingminjie Nan
Xianglong He
Yanan Cao
Research02 Jan 2026
Nature Metabolism

Volume: 8, P: 139-158
Erratum: Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

Rongkun Tao
Yuzheng Zhao
Yi Yang
Amendments and Corrections01 Sept 2017
Nature Methods

Volume: 14, P: 928
AI approaches for predicting progression to acute coronary syndrome among stable coronary heart disease patients

Haozhong Ma
Hexiang Bai
Jian Wu
ResearchOpen Access02 Dec 2025
npj Cardiovascular Health

Volume: 2, P: 1-11
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF.

Jiahuan Chen
Yi Fu
William T. Pu
ResearchOpen Access29 Aug 2017
Nature Communications

Volume: 8, P: 1-13
The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation

Cytokinin is essential for regulation of nodulation. Here, the authors identified a B-type response regulator GmRR11d that governs a transcriptional program associated with nodulation and cytokinin activation essential for systemic regulation of nodulation.

Jiahuan Chen
Zhijuan Wang
Xia Li
ResearchOpen Access10 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy

Conventional X-ray-induced photodynamic therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, the authors develop an organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy of deep tumours.

Xiao Wang
Wenjing Sun
Wei Huang
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-9
A bioinspired polymeric membrane-enclosed insulin crystal achieves long-term, self-regulated drug release for type 1 diabetes therapy

This article presents a polymeric membrane-enclosed insulin crystal equipped with physiological signal-sensing microdomains, dubbed ‘smart drug crystals’, that enables long-term, glucose- and β-hydroxybutyrate-dually responsive drug release for type 1 diabetes therapy.

Jianchang Xu
Yang Zhang
Zhen Gu
Research26 Feb 2025
Nature Nanotechnology

Volume: 20, P: 697-706
Organic phosphors with bright triplet excitons for efficient X-ray-excited luminescence

Organic, metal-free materials that act as efficient X-ray scintillators could bring new opportunities for X-ray imaging.

Xiao Wang
Huifang Shi
Wei Huang
Research11 Jan 2021
Nature Photonics

Volume: 15, P: 187-192
CCl₄ emissions in eastern China during 2021–2022 and exploration of potential new sources

The Montreal Protocol globally phased out ozone-layer depleting CCl₄ by 2010. However, atmospheric measurements show eastern China emitted ~7.6 gigagrams/year in 2021–2022. Further, industrial sources of ongoing CCL₄ emissions are identified.

Bowei Li
Jiahuan Huang
Xuekun Fang
ResearchOpen Access26 Feb 2024
Nature Communications

Volume: 15, P: 1-8
The prediction of foreign language achievement on social competence in Chinese adolescent EFL learners

Jiahuan Zhang
Man Wang
Wen Ma
ResearchOpen Access11 May 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-7
An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs

Orally administrable and glucose-responsive worm-like micelles have been developed to protect insulin in the gastrointestinal tract, enhance its intestinal absorption, accumulate in the liver and enable efficient and safe blood-glucose management.

Kangfan Ji
Xiangqian Wei
Zhen Gu
Research02 Sept 2024
Nature Nanotechnology

Volume: 19, P: 1880-1891
A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.

Libing Mu
Zhongyuan Tu
Yan Shi
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

Genetically encoded iNap sensors allow imaging of NADPH with high spatiotemporal resolution in living systems. The iNaps cover physiologically relevant NADPH concentrations and are demonstrated in mammalian cells and live zebrafish.

Rongkun Tao
Yuzheng Zhao
Yi Yang
Research05 Jun 2017
Nature Methods

Volume: 14, P: 720-728
Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis

Jiahuan Chen
Xiaodong Liang
Bing Zhang
ResearchOpen Access30 Jan 2020
Cell Death & Disease

Volume: 11, P: 1-15
A subjective and objective fusion visual fatigue assessment system for different hardware and software parameters in SSVEP-based BCI applications

Peiyuan Tian
Guanghua Xu
Qingqiang Wu
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
A Nucleus-Encoded Chloroplast Protein YL1 Is Involved in Chloroplast Development and Efficient Biogenesis of Chloroplast ATP Synthase in Rice

Fei Chen
Guojun Dong
Yanchun Yu
ResearchOpen Access02 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Efficient removal of ammonia–nitrogen in wastewater by zeolite molecular sieves prepared from coal fly ash

Qianyang Jiang
Jiahuan He
Xiaoling Xu
ResearchOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Yinghao Cao
Xin Zheng
Shan Tian
ResearchOpen Access30 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-10
Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research

Jiahuan Chen
Qian Zhou
Kang Ning
ResearchOpen Access28 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway

Rilin Deng
Chaohui Zuo
Haizhen Zhu
Research22 Sept 2020
Cellular & Molecular Immunology

Volume: 17, P: 1163-1179
Network pharmacology of iridoid glycosides from Eucommia ulmoides Oliver against osteoporosis

Ting Wang
Liming Fan
Yang Li
ResearchOpen Access06 May 2022
Scientific Reports

Volume: 12, P: 1-17
Elimination of CD4^lowHLA-G⁺ T cells overcomes castration-resistance in prostate cancer therapy

Chao Wang
Jiahuan Chen
Wei-Qiang Gao
Research08 Oct 2018
Cell Research

Volume: 28, P: 1103-1117
Heterogeneous circRNA expression profiles and regulatory functions among HEK293T single cells

Chaofang Zhong
Shaojun Yu
Kang Ning
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis

Wenhua Yu
Fang Zhang
Bing Zhang
ResearchOpen Access13 Apr 2017
Cell Death & Disease

Volume: 8, P: e2744

Search

Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes

Erratum: Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

AI approaches for predicting progression to acute coronary syndrome among stable coronary heart disease patients

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation

Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy

A bioinspired polymeric membrane-enclosed insulin crystal achieves long-term, self-regulated drug release for type 1 diabetes therapy

Organic phosphors with bright triplet excitons for efficient X-ray-excited luminescence

CCl₄ emissions in eastern China during 2021–2022 and exploration of potential new sources

The prediction of foreign language achievement on social competence in Chinese adolescent EFL learners

An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis

A subjective and objective fusion visual fatigue assessment system for different hardware and software parameters in SSVEP-based BCI applications

A Nucleus-Encoded Chloroplast Protein YL1 Is Involved in Chloroplast Development and Efficient Biogenesis of Chloroplast ATP Synthase in Rice

Efficient removal of ammonia–nitrogen in wastewater by zeolite molecular sieves prepared from coal fly ash

Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research

The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway

Network pharmacology of iridoid glycosides from Eucommia ulmoides Oliver against osteoporosis

Elimination of CD4^lowHLA-G⁺ T cells overcomes castration-resistance in prostate cancer therapy

Heterogeneous circRNA expression profiles and regulatory functions among HEK293T single cells

Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis

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