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Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

Wu and colleagues present the efficacy and safety results from the phase 3 SCORES trial evaluating suvemcitug plus chemotherapy in persons with platinum-refractory or resistant recurrent ovarian cancer.

The leather industry is at a pivotal moment on its path towards sustainability. Although many bio-based leather alternatives can reduce environmental impact, we need clear definitions of such alternatives to guide materials innovations that truly bring them into the mainstream, sustainable market, as highlighted in a recent court ruling.

Mid-infrared 2 μm InAs/InP quantum-dot lasers is first demonstrated, with a low threshold current density of 118 A cm⁻² per layer and a maximum operating temperature of 50 °C.

Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis in mice by restoring macrophage efferocytosis and suppress STING pathway activation, offering a promising nanotechnology-based therapeutic strategy.

Water splitting provides an appealing route to generating carbon-neutral fuel, however the scarcity and cost of platinum, often used as a catalyst, necessitates a search for alternatives. Here, authors show cobalt atoms in ruthenium nanosheets to afford excellent hydrogen production activities.

Granulosa cells are the key lineage driving continuous folliculogenesis. Here, the authors reveal that the transcription factor Fosl2 reconfigures chromatin state in these cells and coordinates vital signalling pathways for ovulation and reproduction.

Identifying intermediates during phase transitions is critical for our understanding of correlated materials, but difficult to achieve experimentally. Here, the authors report a surface coordination route to stabilize and directly image a phase-transition intermediate during the metal-insulator transition in vanadium dioxide.

Reductive coupling of CO, a relatively inert molecule, enables its incorporation into both simple building block chemicals as well as more complex synthetic targets. Here, the authors exploit the reactivity of rhodium porphyrin complexes, using photoirradiative conditions to produce manifold reactive pathways after CO binding to the metal center.

Macrophage-augmented organoids integrate macrophages into organoids that are cultured from human liver tissue for analysis of immune responses during three different viral infections.

The local coordination environment determines the properties of single-atom catalysts. Here, authors develop a thermal replacement method to fine tune the coordination structure of cobalt-based single-atom catalysts and study their activity toward carbon dioxide electroreduction.

Individual antibodies identified in the blood of people triple-vaccinated against SARS-CoV-2 predominantly bind spike protein and are highly effective at neutralizing SARS-CoV-2 variants, including Omicron (B.1.1.529).

Targeted sequencing panels such as MSK-IMPACT have been successfully used to profile solid tumours in clinical settings. Here, the authors develop and implement the MSK-IMPACT Heme sequencing panel and platform to profile haematologic malignancies using paired tumor and normal tissues.

Enteric viral diseases pose major global health burdens. Here, Xu et al. establish macrophage-augmented intestinal organoids to study pathophysiology and antiviral response of enteric viral infections. The organoids also facilitate testing of combination treatments that target virus infection and inflammatory signalling.

High-performance hydroxide exchange membrane fuel cells rely on the anode loading of platinum-group metals. Here, the authors report a highly active hydrogen oxidation electrocatalyst which contains atomically dispersed Ir on Mo2C nanoparticles supported on a carbon substrate.

The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.

The NEMO series of genetically encoded calcium indicators report calcium activity in neuronal and non-neuronal cells with high signal-to-baseline ratio, which is shown in neuronal culture, slice preparations, in vivo and in planta.

TRIM66 protein has an N-terminal tripartite motif and a C-terminal PHD Bromodomain. Here the authors show the specific histone modification recognition of TRIM66-PHD-Bromodomain through crystallography and biochemistry assay, and further reveal that TRIM66 recognition of certain histone modification is important for DNA damage repair in ESCs.

Plants can rapidly close stomata to restrict pathogen entry into leaves. Here the authors show that phosphorylation of villin3 by mitogen-activated protein kinases modulates actin remodeling to activate stomatal defense in Arabidopsis.

The precise rule of replication origin selection and activation in metazoans remains unclear. Here, the authors identify NFIB as a genome organizer and replication pioneer by facilitating nucleosome remodeling and chromatin assembly of the pre-RC.

Here, the authors report a strategy to fabricate multi-wavelength circularly polarized light photodetectors consisting of bilayer donor-acceptor heterojunctions with chiral active layers.

Early prediction of AKI-related clinical events and timely intervention for high-risk patients could improve outcomes. Here, the authors show a deep learning model that can identify patients with acute kidney injury (AKI) who are at high risk of death or dialysis at certain time points.

COVID-19-convalescent individuals maintain a strong neutralizing antibody response to SARS-CoV-2 that has cross-reactivity to SARS-CoV and MERS-CoV. Neutralizing antibody titres depend on the severity of the disease and are positively correlated with the frequency of CXCR3⁺ T follicular helper cells and lymphocyte counts.

Engineering the coordination environment of single atom catalysts offers to opportunity to optimize electrocatalytic activity. In this work, the authors prepare an unsymmetrical Cu-S₁N₃ single atom site on porous carbon with high performance in the oxygen reduction reaction.

Han et al. report that the Hippo pathway kinases LATS1 and LATS2 phosphorylate the heavy metal response transcription factor MTF1, leading to attenuation of heavy metal response gene transcription and cellular detoxification.

In response to environmental threats, such as visual looming stimuli, mice either freeze or escape. Here the authors demonstrate that these two behaviors are mediated by separate tectofugal pathways formed by parvalbumin-positive neurons in the superior colliculus.

The production and titration of the SARS-CoV-2 S pseudotyped virus using a VSV-based pseudovirus production system in this protocol enable its use under biosafety level 2 conditions as well as in a neutralization assay to assess the level of neutralizing antibodies or molecular inhibitors in a sample.

The MAPK cascade scaffolding protein IQGAP1, although dispensable for normal epithelial homeostasis, is required for RAS- and RAF-driven tumorigenesis in mouse tumor models. Accordingly, peptide-specific disruption of the interaction between IQGAP1 and ERK1/2 can bypass acquired resistance of vemurafenib-treated BRAF-mutant melanomas and extend the life span of tumor-bearing mice.