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Transient hepatic reconstitution of trophic factors enhances aged immunity

Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.

Mirco J. Friedrich
Julie Pham
Feng Zhang
ResearchOpen Access17 Dec 2025
Nature

Volume: 650, P: 481-489
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

Hongyu Chen
Dangliang Liu
Xiao Wang
Research22 Mar 2024
Nature Biotechnology

Volume: 43, P: 194-203
Genetic analyses support the contribution of mRNA N⁶-methyladenosine (m⁶A) modification to human disease heritability

Quantitative trait locus (QTL) mapping of N⁶-methyladenosine (m⁶A) in human cells highlights the role of RNA-binding proteins, RNA secondary structure and context-dependent m⁶A effects. m⁶A QTLs are enriched in loci associated with immune and blood-related traits.

Zijie Zhang
Kaixuan Luo
Chuan He
Research29 Jun 2020
Nature Genetics

Volume: 52, P: 939-949
Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap

This protocol for imaging-based highly multiplexed in situ profiling of the spatial transcriptome uses three methods: antibody-based protein comapping with STARmap PLUS, ribosome-bound mRNA mapping with RIBOmap and spatiotemporal transcriptome mapping with TEMPOmap.

Jingyi Ren
Hu Zeng
Xiao Wang
Protocols30 Sept 2025
Nature Protocols

Volume: 21, P: 1629-1661

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Transient hepatic reconstitution of trophic factors enhances aged immunity

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability

Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap

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Genetic analyses support the contribution of mRNA N⁶-methyladenosine (m⁶A) modification to human disease heritability