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Showing 1–3 of 3 results
Advanced filters: Author: Jialiu Zeng Clear advanced filters

  • Difficulty with purification, structural heterogenicity, and limited water solubility of β-glucans has significantly limited their therapeutic applications. Here, the authors report the synthesis of (1→6)-β-glucose-branched poly-amido-saccharides as glycan-mimetics and demonstrate macrophage stimulation and polarization.

    • Ruiqing Xiao
    • Jialiu Zeng
    • Mark W. Grinstaff
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • In NAFLD, high levels of fatty acids in the liver impair lysosomal acidification. Here, the authors report the synthesis of novel biodegradable acid-activated acidifying nanoparticles that re-acidify lysosomes, restore autophagy, and reverse fasting hyperglycemia and hepatic steatosis in fat mice.

    • Jialiu Zeng
    • Rebeca Acin-Perez
    • Mark W. Grinstaff
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Fessler and colleagues report that loss of the IFN-γ-induced GTPase IRGM1 results in autoinflammatory disease. Deficient IRGM1 activity led to defective lysosomal maturation and impaired mitophagy, prompting the release of cytosolic mtDNA and thereby activating the cGAS–STING pathway.

    • Prashant Rai
    • Kyathanahalli S. Janardhan
    • Michael B. Fessler
    Research
    Nature Immunology
    Volume: 22, P: 312-321