Sterically hindered aryl C-glycosides are biologically important, yet their efficient, stereoselective synthesis remains challenging because severe anomeric congestion limits existing glycosyl cross-coupling methods with bulky aryl partners. Here, the authors report a ligand-enabled stereospecific Pd-catalyzed coupling delivering hindered aryl C-glycosides.
- Bo Yang
- Shuai Chen
- Feng Zhu
