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Showing 1–4 of 4 results
Advanced filters: Author: Jian-Da Lin Clear advanced filters

  • Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoietic compartment sufficient for this protective effect.

    • Constance McElrath
    • Vanessa Espinosa
    • Sergei V. Kotenko
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Zhu Chen, Sai-Juan Chen, Wei-Li Zhao and colleagues identify recurrent loss-of-function mutations in the RNA helicase gene DDX3X in 20% of subjects with natural killer/T-cell lymphoma (NKTCL) in their study. The results suggest that DDX3X acts as a tumor suppressor and that its inactivation leads to poor clinical outcome.

    • Lu Jiang
    • Zhao-Hui Gu
    • Sai-Juan Chen
    Research
    Nature Genetics
    Volume: 47, P: 1061-1066