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Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation

It has been thought that a switch by the muscle from oxidative phosphorylation to glycolysis is associated with the development of insulin resistance. Jiandie Lin and colleagues now show that transgenic mice that undergo this switch, due to modest overexpression of Baf60c, are actually more glucose tolerant and insulin sensitive compared to wild-type mice when both are placed on a high-fat diet, suggesting the switch is actually an adaptive process.

Zhuo-Xian Meng
Siming Li
Jiandie D Lin
Research07 Apr 2013
Nature Medicine

Volume: 19, P: 640-645
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.

Tongyu Liu
Lin Mi
Siming Li
ResearchOpen Access13 May 2020
Nature Communications

Volume: 11, P: 1-15
The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

Interorgan communications play key roles in the regulation of whole-body energy metabolism. Here, the authors report the myokine Musclin as a negative regulator of beige adipose thermogenesis and systemic energy homeostasis through Tfr1/PKA signalling mediated muscle fat crosstalk.

Lu Jin
Shuang Han
Zhuo-Xian Meng
ResearchOpen Access19 Jul 2023
Nature Communications

Volume: 14, P: 1-23
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

Here the metabolic transcriptional regulator PGC-1alpha is identified as a component of the circadian clock in mammals, which regulates glucose and lipid homeostasis and energy metabolism. Mice lacking PGC-1alpha in their liver and muscle show abnormal daily rhythms of activity, body temperature and metabolic rate, correlated with the disruption of clock genes.

Chang Liu
Siming Li
Jiandie D. Lin
Research02 May 2007
Nature

Volume: 447, P: 477-481
The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation

As opposed to circulating factors that promote energy expenditure, hormones that suppress energy expenditure have remained largely elusive. Here, Wang et al. show that the hepatokine Tsukushi is upregulated in obesity and inhibits sympathetic activity and thermogenesis in fat by promoting whitening.

Qiuyu Wang
Vishal P. Sharma
Jiandie D. Lin
Research14 Jan 2019
Nature Metabolism

Volume: 1, P: 251-260
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Jiandie Lin
Hai Wu
Bruce M. Spiegelman
Research15 Aug 2002
Nature

Volume: 418, P: 797-801
Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity

Inhibiting the cytosolic enzyme histone deacetylase 6 in the periphery is sufficient to improve leptin sensitivity and metabolic outcomes in diet-induced obese mice.

Işın Çakır
Colleen K. Hadley
Roger D. Cone
Research17 Jan 2022
Nature Metabolism

Volume: 4, P: 44-59
Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional activity in response to LXR activation.

Xu-Yun Zhao
Xuelian Xiong
Jiandie D. Lin
ResearchOpen Access30 Jul 2018
Nature Communications

Volume: 9, P: 1-14
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN

Ubiquitin-specific protease 14 (USP14) is a proteasome-associated deubiquitinating enzyme with known roles in physiology and disease. Here the authors show that fatty acid synthase (FASN) is a substrate of USP14, and that by stabilizing FASN, it plays a role in hepatosteatosis.

Bin Liu
Shangwen Jiang
Minjia Tan
ResearchOpen Access13 Nov 2018
Nature Communications

Volume: 9, P: 1-12
The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

The brown fat-derived neuregulin 4 regulates hepatic lipid homeostasis and whole-body insulin sensitivity

Guo-Xiao Wang
Xu-Yun Zhao
Jiandie D Lin
Research17 Nov 2014
Nature Medicine

Volume: 20, P: 1436-1443
GPNMB: expanding the code for liver–fat communication

Interorgan communication is emerging as a critical contributor to nutrient and energy homeostasis. A new study has identified a secreted liver factor that stimulates lipid synthesis in white adipose tissue and exacerbates obesity and insulin resistance.

Henry Kuang
Jiandie D. Lin
News & Views06 May 2019
Nature Metabolism

Volume: 1, P: 507-508

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