Nature Search

BPTF regulates androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction

BPTF is a scaffolding subunit of the nucleosome remodeling factor (NURF) complex. Here the authors show that BPTF is upregulated in prostate cancer cells, increases chromatin accessibility at Androgen Receptor (AR)-binding sites, and stabilizes the AR-FOXA1 complex.

Hee-Young Jeon
Sudeep Khadka
Jianfei Qi
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 17, P: 1-18
Regulation of androgen receptor expression by enhancer elements in prostate cancer

Sudeep Khadka
Hee-Young Jeon
Jianfei Qi
ReviewsOpen Access16 Jan 2026
Experimental & Molecular Medicine

P: 1-5
RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites

This study reveals that RNA silencing component Argonaute 2 (AGO2) loads small RNAs at endoplasmic reticulum–chloroplast membrane contact sites with the help of RNA helicase 3 (RH3), which also enhances the loading of viral-derived small RNAs. These findings highlight the connections between RNA silencing, viral replication, and plant antiviral resistance.

Juan Huang
Juan Du
Xiaoming Zhang
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-17
Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8⁺ T cells activate host CD4⁺ T cells to control tumors with antigen loss

Xiao et al. report that adoptively transferred tumor-specific CD8⁺ interleukin-9-producing cytotoxic T cells promote the recruitment and activation of host effector CD4⁺ T cells to control the outgrowth of tumors with antigen loss.

Liuling Xiao
Rui Duan
Qing Yi
Research03 Apr 2025
Nature Cancer

Volume: 6, P: 718-735
Photoredox cobalt-catalyzed asymmetric desymmetric reductive coupling of cyclobutenes with alkynes

The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is attractive due to the unique reactivity and cost-effectiveness of cobalt catalysts. Here, the authors report an asymmetric desymmetric reductive coupling of electronically unbiased succinimide-containing cyclobutenes with internal alkynes via photoredox and cobalt dual catalysis.

Tianlong Zeng
Yuyang He
Jun Zhu
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-9
Visualizing single-molecule conformational transition and binding dynamics of intrinsically disordered proteins

Intrinsically disordered proteins (IDPs) are highly dynamic and play pivotal roles in cellular processes but can be difficult to study. Here, the authors develop a single-molecule nanocircuit for the real-time monitoring of c-Myc conformational transitions and their interaction with ligands.

Wenzhe Liu
Limin Chen
Xuefeng Guo
ResearchOpen Access25 Aug 2023
Nature Communications

Volume: 14, P: 1-12
Genetic overlap between schizophrenia and cognitive performance

Jianfei Zhang
Hao Qiu
Yanmin Peng
ResearchOpen Access05 Mar 2024
Schizophrenia

Volume: 10, P: 1-7
Ancient ceramics restoration method based on image processing texture stitching

Qi Zheng
Hui Yang
Dahai Liao
ResearchOpen Access09 Dec 2024
Heritage Science

Volume: 12, P: 1-16
Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation

Mechanisms underlying sex associated differences in the role of androgen receptor (AR) in melanoma are unclear. Here the authors show that androgen-activated AR transcriptionally upregulates fucosyltransferase 4, which fucosylates L1CAM and promotes melanoma invasiveness by disrupting adherens junctions.

Qian Liu
Emma Adhikari
Eric K. Lau
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-20
Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis

Shi and colleagues show that PUS7 controls tRNA pseudouridylation and codon-specific translation to fuel glioblastoma tumorigenesis, and discover a PUS7 inhibitor that delays tumor growth in glioblastoma models.

Qi Cui
Kailin Yin
Yanhong Shi
Research16 Aug 2021
Nature Cancer

Volume: 2, P: 932-949
Molecularly Targeted Therapy of Human Hepatocellular Carcinoma Xenografts with Radio-iodinated Anti-VEGFR2 Murine-Human Chimeric Fab

Jianfei Huang
Qi Tang
Jin Zhu
ResearchOpen Access29 May 2015
Scientific Reports

Volume: 5, P: 1-9
Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells

Qi Lai
Haiyong Wang
Zhenzong Du
Research09 Feb 2018
Oncogene

Volume: 37, P: 2302-2312
MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression

Sijia Liu
Binle Tian
Caicun Zhou
ResearchOpen Access22 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-15
Water-richness evaluation method and application of clastic rock aquifer in mining seam roof

Mei Qiu
Zhendong Shao
Jianfei Zhao
ResearchOpen Access18 Mar 2024
Scientific Reports

Volume: 14, P: 1-23
Ubiquitin ligases in oncogenic transformation and cancer therapy

Ubiquitin ligases (E3s) participate in many cellular processes, including cell cycle progression and cell death. This Review by Senftet al. discusses how deregulation of E3s can lead to tumorigenesis and highlights the opportunities for targeting E3s as an anticancer therapy.

Daniela Senft
Jianfei Qi
Ze'ev A. Ronai
Reviews15 Dec 2017
Nature Reviews Cancer

Volume: 18, P: 69-88
Marked impacts of transient conditions on potential secondary organic aerosol production during rapid oxidation of gasoline exhausts

Jinsheng Zhang
Jianfei Peng
Hongjun Mao
ResearchOpen Access05 Jun 2023
npj Climate and Atmospheric Science

Volume: 6, P: 1-9
Evaluation of the influence of freeze–thaw cycles on the joint strength of granite in the Eastern Tibetan Plateau, China

Lirong Qi
Jiading Wang
Jianfei Ma
ResearchOpen Access15 Oct 2024
Scientific Reports

Volume: 14, P: 1-20
Learning accurate personalized survival models for predicting hospital discharge and mortality of COVID-19 patients

Neeraj Kumar
Shi-ang Qi
Russell Greiner
ResearchOpen Access16 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
The intensification of metallic layered phenomena above thunderstorms through the modulation of atmospheric tides

Bingkun Yu
Xianghui Xue
Xiushu Qie
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells

Lingling Fan
Songhui Xu
Jianfei Qi
ResearchOpen Access01 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-16
Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines

Stephen Wilson
Jianfei Qi
Fabian V. Filipp
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-15

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