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Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.

Jiang-Fei Li
Wei-Wei Xu
Mengchun Ye
ResearchOpen Access24 May 2021
Nature Communications

Volume: 12, P: 1-9
Ni-catalyzed benzylic β-C(sp³)–H bond activation of formamides

The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.

Rong-Hua Wang
Wei-Wei Xu
Mengchun Ye
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-9
Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

Cuifeng Li
Yuxin Li
Wanli Liu
Research08 Jul 2025
Nature Biomedical Engineering

Volume: 9, P: 2043-2067
Closed-loop chemical recycling of cross-linked polymeric materials based on reversible amidation chemistry

Closed-loop chemical recycling provides a solution to the end-of-use problem of synthetic polymers but the design of dynamic bonds for preparing chemically recyclable cross-linked polymers remains challenging. Here, the authors report a dynamic reversible amidation reaction between maleic anhydrides and secondary amines.

Bo Qin
Siyuan Liu
Xi Zhang
ResearchOpen Access09 Dec 2022
Nature Communications

Volume: 13, P: 1-9

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Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides

Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections

Closed-loop chemical recycling of cross-linked polymeric materials based on reversible amidation chemistry

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Ni-catalyzed benzylic β-C(sp³)–H bond activation of formamides