The myeloperoxidase homolog, PXN, is secreted into the hemolymph of crayfish and binds to the white spot syndrome virus (WSSV) protein, VP28, extracellularly. PXN-VP28 then interacts with LGBP, which in turn promotes AP-1 nuclear translocation and expression of Cru1, thereby inhibiting WSSV assembly and crayfish reinfection.
- Xiao-Tong Cao
- Gang Lu
- Jiang-Feng Lan
