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Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pathway in a study with male mice.

Qian Ye
Yi Liu
Ni Tang
ResearchOpen Access14 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Evidence of triggered star formation in the Pillars of Creation from JWST observations

JWST reveals 253 YSO candidates in the Pillars of Creation, concentrated along the pillar edges with tentative age gradients and an enhanced star formation rate within 1 Myr. These findings suggest that some may have formed via triggered star formation.

Jing Wen
Bingqiu Chen
Biwei Jiang
Research21 Oct 2025
Nature Astronomy

Volume: 9, P: 1845-1853
Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects

Zhen Yang
Hongmei Zhang
Qing Su
ResearchOpen Access25 Nov 2016
Scientific Reports

Volume: 6, P: 1-6
Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis

Zhen Yang
Chonghuai Yan
Qing Su
ResearchOpen Access17 Nov 2016
Scientific Reports

Volume: 6, P: 1-8

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