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Showing 1–5 of 5 results

Advanced filters: Author: Jibril Hirbo Clear advanced filters

Recommendations for responsible use of population descriptors in polygenic risk score development

In this Perspective, authors from the Polygenic Risk Methods Development (PRIMED) Consortium highlight the ethical and analytical impact of population descriptors in polygenic risk score development and advocate for documenting detailed justifications.

Johanna L. Smith
Clement A. Adebamowo
Quan Sun
Reviews24 Nov 2025
Nature Genetics

Volume: 57, P: 2962-2971
Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer

Padma Sheila Rajagopal
Sonya Reid
Brian D. Lehmann
ResearchOpen Access11 Mar 2025
npj Breast Cancer

Volume: 11, P: 1-9
Convergent adaptation of human lactase persistence in Africa and Europe

This is an issue edsumm for ng1946. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence.

Sarah A Tishkoff
Floyd A Reed
Panos Deloukas
Research10 Dec 2006
Nature Genetics

Volume: 39, P: 31-40
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa

Michael C Campbell
Alessia Ranciaro
Sarah A Tishkoff
Research01 May 2014
Journal of Human Genetics

Volume: 59, P: 349-352
Principles and methods for transferring polygenic risk scores across global populations

This Review summarizes the genetic and non-genetic factors that impact the transferability of polygenic risk scores (PRSs) across populations, highlighting the technical challenges of existing PRS construction methods for diverse ancestries and the emerging resources for more widespread use of PRSs.

Linda Kachuri
Nilanjan Chatterjee
Tian Ge
Reviews24 Aug 2023
Nature Reviews Genetics

Volume: 25, P: 8-25