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Communications Biology (1)

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Advanced filters: Author: Jichuan Geng Clear advanced filters

Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury

This study identifies a role for AIF acetylation in triggering necrotic chromatinolysis and reveals that blocking the late stage of necrosis by deacetylating AIF could offer a potential therapeutic approach for necrosis-associated diseases.

Chen Hu
Jichuan Geng
Shengping Zhang
ResearchOpen Access27 May 2025
Communications Biology

Volume: 8, P: 1-17

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Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury

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