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Showing 1–6 of 6 results
Advanced filters: Author: Jicong Cao Clear advanced filters

  • Converting waste plastics into liquid fuels holds great promise for advancing the circular economy but is challenged by poor selectivity and unwanted methane byproduct formation. Here, the authors present a Ru1-ZrO2 catalyst that efficiently upcycles plastic waste into high-value jet fuel–range hydrocarbons with minimal methane production.

    • Jicong Yan
    • Guanna Li
    • Xiang Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • The engineering of 5′ UTRs that modulate protein expression remains a great challenge. Here we leverage synthetic biology and computational design to develop a high-throughput strategy to design, screen, and optimize 5′ UTRs that enhance protein expression for non-viral gene therapies.

    • Jicong Cao
    • Eva Maria Novoa
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.

    • William C. W. Chen
    • Leonid Gaidukov
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.

    • Pablo Perez-Pinera
    • Ningren Han
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • The ability to combine the production of multiple biologics into a single ‘on demand’ system could help in situations where resources are limited. Here the authors demonstrate a proof-of-concept approach for the co-production of three biologics, allowing singular, mixed and combination drug products.

    • Jicong Cao
    • Pablo Perez-Pinera
    • Timothy K. Lu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13