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Advanced filters: Author: Jiefei Geng Clear advanced filters

Modulating TRADD to restore cellular homeostasis and inhibit apoptosis

The adaptor protein TRADD is a regulator of both cellular homeostasis and apoptosis, and represents a potential therapeutic target for human diseases.

Daichao Xu
Heng Zhao
Junying Yuan
Research23 Sept 2020
Nature

Volume: 587, P: 133-138
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

TNFα can promote three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. Here the authors show that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision.

Jiefei Geng
Yasushi Ito
Junying Yuan
ResearchOpen Access25 Aug 2017
Nature Communications

Volume: 8, P: 1-12
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

Amanda Tomie Ouchida
Yingbo Li
Junying Yuan
ResearchOpen Access26 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-14
Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells

Drug-responsive domains developed from human carbonic anhydrase 2 and stabilized by acetazolamide tightly regulate expression and function of potent cytokines in engineered T cells for adoptive cell therapy

Mara C. Inniss
Sean G. Smith
Dhruv K. Sethi
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-16