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Systemically administered piezoelectric nanoparticles producing nitric oxide and generating direct current under high-intensity focused ultrasound can be used to stimulate deep tissue in the brain, as shown in a mouse model of Parkinson’s disease.

While different types of low-power transistors have been investigated, low voltage rectifiers able to overcome the thermionic limit have not been proposed yet. Here, the authors report the realization of Dirac-source diodes based on graphene/MoS2/graphite heterostructures, showing ideality factors <1 and rectifying ratios exceeding 10⁸ at room temperature.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

New two-dimensional semiconductors may exhibit properties beyond inherent semiconducting attributes. Here the authors report protonated semiconducting III–V-derived van der Waals crystals with memristive properties.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Here, authors demonstrate the electrohydrodynamic printing of alkylated 3,4-dihydroxy-L-phenylalanine functionalized MXene (AD-MXene) ink. The AD-MXene outperforms vacuum-deposited Au and Al electrodes, providing thin film transistors with good environmental stability due to its hydrophobicity.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Multi resonance thermally activated delayed fluorescence emitters are the next-generation blue dopants for organic light-emitting diodes. Here, the authors develop two isomeric emitters with hybridized long-range and short-range charge transfer excited states and realize device efficiency of 30.8%.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

In this study, Ma et al. demonstrated that asymmetric hydrogen-bonding interaction between chiral organic spacer and inorganic frameworks plays a key role in promoting the chiroptical activity of chiral perovskites.

Achieving uniform Li plating in solid-state batteries is key for their practical application. Here, the authors integrate a silver-doped lithium argyrodite layer in initially anode-free all-solid-state batteries, promoting uniform lithium plating and cell operation under a low stack pressure of 2 MPa through silver exsolution.

Using free association and natural language methods, we show that individuals with higher subjective well-being generate thoughts semantically closer to ‘friend’ but not to ‘money,’ highlighting the value of social relationships in happiness.

FRET sensors hardly achieve visualization of spatiotemporal dynamics of protein activity in vivo. Here the authors present intensiometric small GTPase biosensors based on dimerization-dependent fluorescent proteins that enable monitoring of activity of small GTPases in the brains of behaving mice at a single spine resolution.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Mechanoluminescent platforms have emerged in smart wearable technology, however, their luminescence performance often deteriorates under extreme elastic conditions owing to a misinterpretation of polymer matrix behavior. Here, the authors study the role of polymer matrices in mechanoluminescence via elasticity-driven interface-triboelectric effects providing insights into selecting optimal polymers for smart wearable applications.

Inducible genetic mosaics can provide information about cellular lineages that are otherwise difficult to obtain. Here the authors report a mosaic knockout system called Red2Flpe-SCON, which allows lineage tracing of wild-type and mutant cells using a multicolour fluorescent reporter in mice.

In-sensor computing minimizes latency by directly processing data at the point of capture. Here, authors optimize this process by integrating polarization-sensitive detectors into the computing framework, enabling the superposition of two filtering operations within a single circuit.

SynapShot combines ddFPs with engineered synaptic adhesion molecules for real-time observation of the structural plasticity of synapses in cultured cells and animals.

A laser-based patterning method enables the fast fabrication of high-quality two- and three-dimensional features in polydimethylsiloxane for microfluidics and biomedical applications.

Biobased polymers provide a sustainable alternative to petroleum-based plastics. In this study, the authors engineered Escherichia coli to biosynthesize poly(ester amide)s with customizable amino acids, expanding options for renewable, biobased polymer production.

Developing photoredox catalysts with long-lived excited states that feature highly cathodic oxidation potentials is imperative. Here, the authors demonstrate the C–C cross-coupling catalytic utility of two-coordinate LLCT-active Au(I) complex photocatalysts with visible-light absorption and a 210 ns-long excited-state lifetime.

In the formation of physical hydrogels from triblock copolymers, formation of polymer loops can result in topological defects. Here, the authors report the development of hydrogels from oppositely charged copolymers which assembled to form branched and bridge-rich networks.

The use of membranes under harsh conditions, particularly involving the separation of complex organic solvents, remains challenging. Here the authors demonstrate an ultrathin organosiloxane polymer membrane using initiated chemical vapor deposition to effectively separate solutes within the molecular weight range of 150–300 g mol⁻¹.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

A bottleneck in solid-state batteries is the solid electrode-electrolyte interface being maintained over repeated cycles. Here, the authors use an epitaxial model system to probe and control the interface in real time.

This study finds that stimulation of muscarinic acetylcholine receptors causes long-term depression (LTD) of NMDA receptor–mediated synaptic transmission. This LTD requires the release of Ca²⁺ from IP₃-sensitive stores and involves an interaction between the Ca²⁺ sensor protein hippocalcin, the clathrin adaptor AP2 and NMDA receptors.

Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.

Edge-to-edge metal-semiconductor junctions have the potential to improve the performance of 2D transistors. Here, the authors report a synthetic strategy to fabricate monolayer MoS₂-PtTe₂ heterojunction arrays with sub-1-nm transfer length and enhanced carrier injection compared to vertical 3D metallic contacts.