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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD

RNA sequencing reveals widespread transcriptomic changes across the cerebral cortex in autism spectrum disorder, including primary sensory regions, in addition to association regions, as well as an attenuation of regional identity.

Michael J. Gandal
Jillian R. Haney
Daniel H. Geschwind
ResearchOpen Access02 Nov 2022
Nature

Volume: 611, P: 532-539
Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder

Gene expression patterns have been associated with functional activity patterns in the brain. Here the authors determine how gene expression patterns in the human brain supports brain phenotypes obtained from resting state fMRI imaging, identifying brain regions and genes relevant to autism.

Stefano Berto
Alex H. Treacher
Genevieve Konopka
ResearchOpen Access09 Jun 2022
Nature Communications

Volume: 13, P: 1-11
A gut-derived metabolite alters brain activity and anxiety behaviour in mice

The gut-derived molecule 4-ethylphenol influences complex behaviours in mice through effects on oligodendrocyte function and myelin patterning in the brain.

Brittany D. Needham
Masanori Funabashi
Sarkis K. Mazmanian
Research14 Feb 2022
Nature

Volume: 602, P: 647-653
Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors integrate mRNA expression, miRNA expression, DNA methylation, and histone acetylation datasets from a collection of post mortem brain tissues and identify a convergent molecular subtype of ASD.

Gokul Ramaswami
Hyejung Won
Daniel H. Geschwind
ResearchOpen Access25 Sept 2020
Nature Communications

Volume: 11, P: 1-14
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

Brain genetic co-expression networks pinpoint specific, convergent synaptic pathways—rather than the complement system—through which genetic variation at the C4 locus imparts risk for schizophrenia.

Minsoo Kim
Jillian R. Haney
Michael J. Gandal
Research06 May 2021
Nature Neuroscience

Volume: 24, P: 799-809

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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD

Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

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