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Showing 1–2 of 2 results
Advanced filters: Author: Jillian L. Rourke Clear advanced filters

  • Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs.

    • Kathryn F. Cogger
    • Ankit Sinha
    • M. Cristina Nostro
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1 diabetes.

    • Caterina Iorio
    • Jillian L. Rourke
    • Robert A. Screaton
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13