Argonaute proteins are essential for miRNA function. Now a study in fly and mammalian systems shows that miRNA availability has an effect on the steady-state levels of Argonaute proteins. Argonaute is degraded by the ubiquitin-proteasome pathway, and increased miRNA levels lead to stabilization and accumulation of Argonaute.
- Peter Smibert
- Jr-Shiuan Yang
- Eric C Lai