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Showing 1–7 of 7 results
Advanced filters: Author: Jim Baggen Clear advanced filters

  • The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes promoting viral genome release.

    • Jim Baggen
    • Yue Liu
    • Frank J. M. van Kuppeveld
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • The human enterovirus D68 (EV-D68) is a causative agent of childhood respiratory infections, but despite its prevalence the exact mechanism mediating its cell entry have not been fully established. Here, the authors show how EV-D68 binds to sialic acid on the cell surface to initiate infection.

    • Yue Liu
    • Ju Sheng
    • Michael G. Rossmann
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • Proviral host factors for SARS-CoV-2 infection, cellular processes that are important in SARS-CoV-2 replication and host factors that could be targeted by antiviral therapies for COVID-19 are reviewed.

    • Jim Baggen
    • Els Vanstreels
    • Dirk Daelemans
    Reviews
    Nature Microbiology
    Volume: 6, P: 1219-1232

  • In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. In this Review, van Kuppeveld and colleagues summarize recent insights from enterovirus research, with a special emphasis on NPEVs, and reflect on how recent discoveries may help in the development of new antiviral strategies.

    • Jim Baggen
    • Hendrik Jan Thibaut
    • Frank J. M. van Kuppeveld
    Reviews
    Nature Reviews Microbiology
    Volume: 16, P: 368-381