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PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

Sonia T. Nicolaou
Max Hebditch
Jim Warwicker
ResearchOpen Access11 May 2021
Scientific Reports

Volume: 11, P: 1-7
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

Poly-ADP-ribosylation is a post-translational modification that is countered by poly(ADP-ribose) glycohydrolases (PARGs). In this study, the authors present the crystal structure of poly(ADP-ribose) glycohydrolase (PARGs) in complex with a poly(ADP-ribose) substrate, and reveal that poly(ADP-ribose) glycohydrolase (PARGs) enzymes act predominantly as exo- rather than as endo-glycohydrolases.

Eva Barkauskaite
Amy Brassington
David Leys
ResearchOpen Access06 Aug 2013
Nature Communications

Volume: 4, P: 1-8
Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics

Max Hebditch
Jim Warwicker
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Sequence composition predicts immunoglobulin superfamily members that could share the intrinsically disordered properties of antibody CH1 domains

Max Hebditch
Robin Curtis
Jim Warwicker
ResearchOpen Access29 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
Soluble expression of proteins correlates with a lack of positively-charged surface

Pedro Chan
Robin A. Curtis
Jim Warwicker
ResearchOpen Access26 Nov 2013
Scientific Reports

Volume: 3, P: 1-6
Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons

Nicholas J. Fowler
Christopher F. Blanford
Jim Warwicker
ResearchOpen Access27 Nov 2017
Scientific Reports

Volume: 7, P: 1-12

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PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics

Sequence composition predicts immunoglobulin superfamily members that could share the intrinsically disordered properties of antibody CH1 domains

Soluble expression of proteins correlates with a lack of positively-charged surface

Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons

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