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Showing 1–6 of 6 results
Advanced filters: Author: Jimmy Gollihar Clear advanced filters

  • The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled receptors are more sensitive in this membrane environment.

    • Björn D. M. Bean
    • Colleen J. Mulvihill
    • Vincent J. J. Martin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Symmetrical protein oligomers perform key structural and catalytic functions in nature, but engineering such oligomers synthetically is challenging. Now, oppositely supercharged synthetic variants of normally monomeric proteins have been shown to assemble via specific, introduced electrostatic contacts into symmetrical, highly well-defined oligomers.

    • Anna J. Simon
    • Yi Zhou
    • Andrew D. Ellington
    Research
    Nature Chemistry
    Volume: 11, P: 204-212

  • Expansion of the genetic code to noncanonical amino acids (NCAAs) has been limited by the lack of evolutionary pressure for organismal dependence on the NCAA. Linking bacterial survival to an engineered β-lactamase that requires a non-natural tyrosine analog engenders diverse bacteria with a stable, expanded genetic code.

    • Drew S Tack
    • Jared W Ellefson
    • Andrew D Ellington
    Research
    Nature Chemical Biology
    Volume: 12, P: 138-140

  • This manuscript investigates the binding mode of a potent SARS-CoV-2 neutralizing antibody. N3-1 is escaped by Omicron variants due to altered spike dynamics. This work suggests the need for innovative vaccine designs to combat evolving variants.

    • Jule Goike
    • Ching-Lin Hsieh
    • Jimmy D. Gollihar
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-13

  • Gontu et al. conducted a longitudinal study in COVID patients in which they assessed the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers. Their measurements demonstrate the presence of an optimum window for convalescent plasma donation as well as predictions of the most suitable donor type.

    • Abhinay Gontu
    • Sreenidhi Srinivasan
    • Vivek Kapur
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9