A pentavalent live attenuated vaccine platform, MOPEVACNEW, was engineered to express glycoproteins from all five known pathogenic New World arenaviruses from a modified Mopeia virus. This approach induces robust antiviral antibody responses and sterile protection to prevent severe haemorrhagic fever and mortality in cynomolgus monkeys.
- Stéphanie Reynard
- Xavier Carnec
- Sylvain Baize