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Showing 1–3 of 3 results
Advanced filters: Author: Jin Huk Choi Clear advanced filters

  • The molecular mechanisms that maintain thymic epithelial cell (TEC) identity throughout life are incompletely understood. Here, the authors demonstrate that the transcription factor, Ovol2, maintains post-natal TECs by preventing their epithelial-to-mesenchymal transition.

    • Xue Zhong
    • Nagesh Peddada
    • Bruce Beutler
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Beutler and colleagues identify skywarp (swp) mice, which exhibit a hypomorphic variant of the U5 splicing protein SNRNP40 and aberrant mRNA splicing specifically in lymphocytes and hematopoietic stem and progenitor cells, suggesting alternative splicing influencing immune cell function.

    • Duanwu Zhang
    • Tao Yue
    • Bruce Beutler
    Research
    Nature Immunology
    Volume: 20, P: 1322-1334

  • Increased susceptibility to gastrointestinal infections and colitis can be driven by a failure to maintain intestinal homeostasis. Here, using a forward genetic screen, Song et al. identify and characterise the role of TVP23B in Paneth cell and goblet cell function, and its impact on colitis.

    • Ran Song
    • William McAlpine
    • Emre E. Turer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13